Real Betis will be looking to pull off an unlikely comeback in this last-16 UEFA Europa League clash, as they look to overcome a three-goal deficit against Man United.

The first leg at Old Trafford saw Man United bounce back from their infamous 7-0 Premier League defeat to Liverpool in some style, thrashing Betis 4-1 in a showing that underlined why the Red Devils are favorites to win Europe’s second-tier tournament.

Betis coach Manuel Pellegrini will be hoping Ayoze Pérez’s late strike in the reverse fixture won’t go down as a consolation, while United boss Eric ten Hag is likely to see a seemingly unassailable aggregate lead as an opportunity to rest key players such as Marcus Rashford.

Real Betis host Manchester United at Estadio Benito Villamarín on Thursday, March 16. Kickoff is set for 6.45 p.m. CET local time in Spain (5.45 p.m. GMT in the UK; 1.45 p.m. ET, 10.45 a.m. PT in the US; and at 4.45 a.m. AEST on Friday, March 17, in Australia).